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Gynecol Minim Invasive Ther. 2019 Oct 24;8(4):149-154. doi: 10.4103/GMIT.GMIT_4_19. eCollection 2019 Oct-Dec.

The Management of Heterotopic Pregnancy with Transvaginal Ultrasound-Guided Local Injection of Absolute Ethanol.

Author information

1
Reproductive Medicine Center, 105 Hospital of the People's Liberation Army, Hefei, China.

Abstract

Aims:

The aim of the study is to present five cases of heterotopic pregnancy (HP) patients who received transvaginal ultrasound-guided local injection of absolute ethanol (AE).

Settings and Design:

This was a case series and literature review in Reproductive Medicine Center of the 105th Hospital of the People's Liberation Army.

Materials and Methods:

Five primary infertile women who underwent assisted reproductive technology were diagnosed with HP and treated with local injection of AE (1.0-2.5 ml) under transvaginal ultrasound guidance. The size of intrauterine (IU) and ectopic sacs and the level of serum beta-human chorionic gonadotropin as well as pregnancy outcomes were monitored after treatment.

Statistical Analysis Used:

Not applicable.

Results:

Four of five cases presented with lack of Doppler flow in the injected area after AE injection. Meanwhile, IU pregnancy proceeded well after treatment and delivered a normal newborn. One case received emergency surgery 3 h after local injection of 2.5 ml AE because of the rupture of ectopic gestational sac (GS). An early abortion was identified 7 days after the surgery.

Conclusions:

Transvaginal ultrasound-guided local injection of AE is an alternative nonsurgical treatment for HP, yet overdose injection of AE will increase the risk of ectopic GS rupture.

KEYWORDS:

Absolute ethanol; assisted reproductive technology; heterotopic pregnancy; transvaginal ultrasonography

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