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Biomed Pharmacother. 2020 Jan;121:109635. doi: 10.1016/j.biopha.2019.109635. Epub 2019 Nov 15.

Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives.

Author information

1
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; South Sichuan Institution for Translational Medicine, Luzhou, 646000, Sichuan, PR China; Drug Discovery Research Group, Parham Academy of Biomedical Sciences, The Heritage B-16-10, Selangor, 43300, Malaysia. Electronic address: parham@swmu.edu.cn.
2
Department of Internal Medicine, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
3
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
4
Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
5
Drug Discovery Research Group, Parham Academy of Biomedical Sciences, The Heritage B-16-10, Selangor, 43300, Malaysia.
6
Laboratory of Virology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, 43400, Malaysia.
7
Drug Discovery Research Group, Parham Academy of Biomedical Sciences, The Heritage B-16-10, Selangor, 43300, Malaysia; School of Mathematical, Physical, and Natural Sciences, University of Florence, Firenze, 50134, Italy.
8
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; South Sichuan Institution for Translational Medicine, Luzhou, 646000, Sichuan, PR China.
9
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; South Sichuan Institution for Translational Medicine, Luzhou, 646000, Sichuan, PR China. Electronic address: xzg555898@hotmail.com.

Abstract

Breast cancer is the most common type of cancer among women. Therefore, discovery of new and effective drugs with fewer side effects is necessary to treat it. Sulforaphane (SFN) is an organosulfur compound obtained from cruciferous plants, such as broccoli and mustard, and it has the potential to treat breast cancer. Hence, it is vital to find out how SFN targets certain genes and cellular pathways in treating breast cancer. In this review, molecular targets and cellular pathways of SFN are described. Studies have shown SFN inhibits cell proliferation, causes apoptosis, stops cell cycle and has anti-oxidant activities. Increasing reactive oxygen species (ROS) produces oxidative stress, activates inflammatory transcription factors, and these result in inflammation leading to cancer. Increasing anti-oxidant potential of cells and discovering new targets to reduce ROS creation reduces oxidative stress and it eventually reduces cancer risks. In short, SFN effectively affects histone deacetylases involved in chromatin remodeling, gene expression, and Nrf2 anti-oxidant signaling. This review points to the potential of SFN to treat breast cancer as well as the importance of other new cruciferous compounds, derived from and isolated from mustard, to target Keap1 and Akt, two key regulators of cellular homeostasis.

KEYWORDS:

Apoptosis; Brassicaceae; Breast cancer; Sulforaphane; nrf2

PMID:
31739165
DOI:
10.1016/j.biopha.2019.109635
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