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Bioinformatics. 2019 Nov 18. pii: btz857. doi: 10.1093/bioinformatics/btz857. [Epub ahead of print]

Discovery of disease- and drug-specific pathways through community structures of a literature network.

Author information

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Abstract

MOTIVATION:

In light of the massive growth of the scientific literature, text mining is increasingly used to extract biological pathways. Though multiple tools explore individual connections between genes, diseases, and drugs, few extensively synthesize pathways for specific diseases and drugs.

RESULTS:

Through community detection of a literature network, we extracted 3,444 functional gene groups that represented biological pathways for specific diseases and drugs. The network linked Medical Subject Headings (MeSH) terms of genes, diseases, and drugs that co-occurred in publications. The resulting communities detected highly associated genes, diseases, and drugs. These significantly matched current knowledge of biological pathways and predicted future ones in time-stamped experiments. Likewise, disease- and drug-specific communities also recapitulated known pathways for those given diseases and drugs. Moreover, diseases sharing communities had high comorbidity with each other and drugs sharing communities had many common side effects, consistent with related mechanisms. Indeed, the communities robustly recovered mutual targets for drugs (AUROC = 0.75) and shared pathogenic genes for diseases (AUROC = 0.82). These data show that literature communities inform not just known biological processes but also suggest novel disease- and drug-specific mechanisms that may guide disease gene discovery and drug repurposing.

AVAILABILITY:

Application tools are available at http://meteor.lichtargelab.org.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

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