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Pediatr Infect Dis J. 2019 Dec;38(12):1224-1227. doi: 10.1097/INF.0000000000002473.

Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children.

Author information

1
From the Division of Hospital Medicine, Department of Pediatrics.
2
Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
3
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
4
Division of Critical Care Medicine, Department of Pediatrics. Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Abstract

We performed a prospective cohort study to investigate oseltamivir administration in critically ill children. We found that enteric tube administration of oseltamivir resulted in lower concentrations of its active metabolite compared with oral delivery. These findings could have significant clinical implications, and more studies are required to better understand the effects of administration route on potential lower systemic metabolite exposure.

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