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Curr Pharm Des. 2019 Nov 16. doi: 10.2174/1381612825666191116125525. [Epub ahead of print]

Exosomes in Sepsis and Inflammatory Tissue Injury.

Author information

1
Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Abstract

Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as pro-inflammatory cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we will review the current knowledge on the exosomes in the sepsis and relevant inflammatory tissue injuries.

KEYWORDS:

Exosome; Extracellular vesicle; Inflammatory tissue injury; Integrin; Sepsis; Septic shock; miRNA

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