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Ann Indian Acad Neurol. 2019 Oct-Dec;22(4):506-512. doi: 10.4103/aian.AIAN_293_19. Epub 2019 Oct 25.

Multiple Neurologic Deficits and Cognitive Decline in a Young Woman.

Author information

1
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
2
Department of Neurology, Government Medical College, Kottayam, Kerala, India.
3
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
4
Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.

Abstract

We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia, reversal of albumin globulin ratio, mediastinal adenopathy, ANA positivity, low C3 levels with the CSF being inflammatory and MRI showing extensive hemorrhagic lesions with mass effect. She had a rapidly progressive fatal course over three years with the disease being undiagnosed. This case was presented in the annual meeting of the Indian Academy of Neurology in September 2018.

KEYWORDS:

CNS lymphoma; Clinico-pathologic conference; lymphomatoid granulomatosis; multiple neurologic deficits; neurosarcoidosis

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