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Ann Indian Acad Neurol. 2019 Oct-Dec;22(4):426-431. doi: 10.4103/aian.AIAN_325_18. Epub 2019 Oct 25.

Abnormal Subcortical Volumes and Cortical Thickness in Parkinson's Disease with Impulse Control Disorders.

Author information

1
Department of Clinical Neurosciences, Bengaluru, Karnataka, India.
2
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
3
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Abstract

Background:

The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in patients with PD and ICD.

Objectives:

This study aims to identify changes in volumes of subcortical structures and cortical thickness specific to patients with PD and ICDs.

Methodology:

A total of 11 patients with PD and ICD (PDICD(+)), 15 patients with PD without ICD (PDICD(-)), and 15 healthy controls were analyzed in this study. ICDs were diagnosed and quantified using the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS). Structural imaging was performed on a 3T scanner; volumes of subcortical structures and cortical thickness were obtained using first in FSL and FreeSurfer.

Results:

Significant volume loss of the nucleus accumbens was observed in the PDICD(+) group. Several areas of significant cortical thinning were observed in the PDICD(+) group in comparison PDICD(-) group. Thinning of the left middle temporal gyrus, transverse temporal gyrus, and bilateral temporal poles was observed in the PDICD(+) group. No correlations were observed between QUIP-RS scores and areas of cortical thinning.

Conclusions:

The PDICD(+) group has specific neuroanatomical variations in the nucleus accumbens and temporal lobes, which may contribute to the development of ICD and perhaps predispose a patient to ICDs on exposure to dopamine replacement therapy.

KEYWORDS:

Cortical thickness; Parkinson's disease; impulse control disorder; subcortical volumetry

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