Format

Send to

Choose Destination
World Neurosurg. 2019 Nov 13. pii: S1878-8750(19)32862-1. doi: 10.1016/j.wneu.2019.11.026. [Epub ahead of print]

Comparison of Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation Surgery on Parkinson's Disease-related Pain.

Author information

1
Department of Neurosurgery, The General Hospital of Northern Theater Command (The Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, 83 Wenhua Road, Shenyang 110016, China.
2
Department of Neurosurgery, The General Hospital of Northern Theater Command (The Original General Hospital of Shenyang Military Area Command), PLA Institute of Neurology, 83 Wenhua Road, Shenyang 110016, China. Electronic address: yingquntao@163.com.

Abstract

OBJECTIVE:

This study was to analyze and compare the effects of subthalamic nucleus (STN)-Deep brain stimulation (DBS) and Globus pallidus internus (GPi)-DBS on Parkinson's disease (PD)-related pain.

METHODS:

A retrospective study was performed of 64 patients (28 underwent GPi-DBS, 36 underwent STN-DBS) with PD-related pain in our hospital from January 2017 to July 2019. Numerical Rating Scale (NRS) was used to evaluate the degree of pain preoperatively and 4 months after operation, and the unified PD scale Ⅲ (UPDRS-III) was completed to assess the motor symptoms simultaneously.

RESULTS:

The average NRS score of all 64 patients after operation was 1.09±1.39, which was significantly lower than that before operation (4.44±1.67) (p<0.0001). The improvement rate of NRS was 75%±27% in 28 GPi-DBS patients and 79%±27% in 36 STN-DBS patients, with no significant difference (p=0.577). The improvement rate of NRS and UPDRS-III were significantly correlated in STN-DBS group (r=0.3707, p=0.026), while not significantly correlated in GPi-DBS group (p=0.516).

CONCLUSIONS:

Both GPi-DBS and STN-DBS were effective for PD-related pain and seemed to have similar efficacy. This study provided an important first-step towards different DBS targets for controlling PD-related pain. Follow-up prospective research is an appropriate next-step on the path towards multicenter clinical trials.

KEYWORDS:

Deep Brain Stimulation; Globus pallidus internus; Pain; Parkinson's disease; Subthalamic nucleus

PMID:
31733388
DOI:
10.1016/j.wneu.2019.11.026

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center