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Neuron. 2020 Jan 8;105(1):180-197.e5. doi: 10.1016/j.neuron.2019.09.039. Epub 2019 Nov 12.

A Distinct Class of Bursting Neurons with Strong Gamma Synchronization and Stimulus Selectivity in Monkey V1.

Author information

1
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; International Max Planck Research School for Neural Circuits, Frankfurt am Main, Germany.
2
Max Planck Institute for Brain Research, Frankfurt, Germany; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
3
Institute of Neuroscience and Department of Biology, University of Oregon, Eugene, OR, USA.
4
Max Planck Institute for Brain Research, Frankfurt, Germany.
5
Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
6
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany.
7
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; Max Planck Institute for Brain Research, Frankfurt, Germany.
8
Vanderbilt University, Nashville, TN, USA.
9
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; Max Planck Institute for Brain Research, Frankfurt, Germany; Frankfurt Institute for Advanced Studies, Frankfurt, Germany.
10
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany. Electronic address: martin.vinck@esi-frankfurt.de.

Abstract

Cortical computation depends on interactions between excitatory and inhibitory neurons. The contributions of distinct neuron types to sensory processing and network synchronization in primate visual cortex remain largely undetermined. We show that in awake monkey V1, there exists a distinct cell type (››30% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates and fires in high-frequency bursts. These neurons are more stimulus selective and phase locked to 30- to 80-Hz gamma oscillations than other neuron types. Unlike other neuron types, their gamma-phase locking is highly predictive of orientation tuning. We find evidence for strong rhythmic inhibition in these neurons, suggesting that they interact with interneurons to act as excitatory pacemakers for the V1 gamma rhythm. We did not find a similar class of NW bursting neurons in L2-L4 of mouse V1. Given its properties, this class of NW bursting neurons should be pivotal for the encoding and transmission of stimulus information.

KEYWORDS:

V1; bursting; cell class; cell type; excitatory; gamma; interneuron; orientation tuning; oscillation; synchronization

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