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Neurobiol Aging. 2019 Nov;83:145-149. doi: 10.1016/j.neurobiolaging.2019.03.024.

How do we validate approaches that aim to harness reserve to improve the aging brain?

Author information

1
Pacific Health Research and Education Institute, Honolulu, HI, USA.
2
Department of Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
3
Department of Neuroscience, University of Florida, Gainesville, FL, USA.
4
Department of Neurology, University of California, San Francisco, CA, USA.
5
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: jdisterhoft@northwestern.edu.

Abstract

An accurate assessment of the impact of reserve on cognitive functioning in older individuals with brain pathology requires careful measurement of each and an assessment of the extent to which each influences the other. Studies to integrate information about molecular biology, neuropathology, behavioral aspects of cognitive decline, and cognitive resilience will be of particular importance. In addition, more work is needed to improve our understanding of the effect of systemic factors on brain health and function. It seems likely that, even in later life, the brain's plasticity may allow for a positive response to stimulation. The ultimate goal of this research is to create a validated set of variables and interventions-and to understand the biology underlying them-that are useful not only in describing an individual's cognitive state but also in identifying promising paths for treatment and prevention of cognitive decline.

KEYWORDS:

Assessment; Interventions; Neuropathology; Reserve; Resilience

PMID:
31732018
PMCID:
PMC6859906
[Available on 2020-11-01]
DOI:
10.1016/j.neurobiolaging.2019.03.024

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