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Clin Chest Med. 2019 Dec;40(4):797-810. doi: 10.1016/j.ccm.2019.08.003.

Management of Children with Tuberculosis.

Author information

1
The Children's Hospital at Westmead Clinical School, Level 3 Children's Hospital Westmead, Locked Bag 4001, Hawkesbury Road, Westmead, New South Wales 2145, Australia. Electronic address: Ameneh.khatami@gmail.com.
2
The Children's Hospital at Westmead Clinical School, Level 3 Children's Hospital Westmead, Locked Bag 4001, Hawkesbury Road, Westmead, New South Wales 2145, Australia.

Abstract

Children carry a significant tuberculosis disease burden in settings with poor epidemic control and high levels of transmission. Even in high-resource settings, the diagnosis of tuberculosis in children can be challenging, but an accurate diagnosis can be achieved by adopting a systematic approach. This review outlines the general principles of tuberculosis prevention in children, including epidemic control, infection control, contact tracing and preventive therapy, and vaccination; diagnosing pediatric tuberculosis, including specimen collection and microbiological confirmation, highlighting key differences from adults; and tuberculosis treatment in children, including treatment of severe disease that mostly occurs in young children and drug-resistant tuberculosis.

KEYWORDS:

Child; Diagnosis; Management; Multi-drug resistant; Mycobacterium tuberculosis; Prevention; Treatment; Tuberculosis

PMID:
31731985
DOI:
10.1016/j.ccm.2019.08.003

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