Format

Send to

Choose Destination
Curr Opin Cell Biol. 2019 Nov 12;62:78-85. doi: 10.1016/j.ceb.2019.09.003. [Epub ahead of print]

Novel approaches to link apicobasal polarity to cell fate specification.

Author information

1
Department of Biological Sciences, National University of Singapore, 117583, Singapore; Mechanobiology Institute, National University of Singapore, 117 411, Singapore; Temasek Life-sciences Laboratory, 117604, Singapore; Contributed equally.
2
Institute of Molecular and Cell Biology, ASTAR, Singapore; Contributed equally.
3
Department of Biological Sciences, National University of Singapore, 117583, Singapore; Mechanobiology Institute, National University of Singapore, 117 411, Singapore; CNRS, 117411, Singapore; Contributed equally. Electronic address: dbsvvnr@nus.edu.sg.

Abstract

Understanding the development of apicobasal polarity (ABP) is a long-standing problem in biology. The molecular components involved in the development and maintenance of APB have been largely identified and are known to have ubiquitous roles across organisms. Our knowledge of the functional consequences of ABP establishment and maintenance is far less comprehensive. Recent studies using novel experimental approaches and cellular models have revealed a growing link between ABP and the genetic program of cell lineage. This mini-review describes some of the most recent advances in this new field, highlighting examples from Caenorhabditis elegans and mouse embryos, human pluripotent stem cells, and epithelial cells. We also speculate on the most interesting and challenging avenues that can be explored.

KEYWORDS:

Apico-basal polarity; Differentiation; Single cell; Stem cells

PMID:
31731147
DOI:
10.1016/j.ceb.2019.09.003

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center