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Life Sci. 1988;43(15):1257-60.

Presence of lorazepam in the blood plasma of drug free rats.

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1
Pharmaceutical Research Department, F. Hoffman-La Roche & Co., Ltd., Basle, Switzerland.

Abstract

Lorazepam has been identified in the blood plasma of non-medicated rats by means of HPLC and gas chromatography combined with mass spectrometry. It was found to be present in about 1 ng per ml blood plasma. This pharmacologically highly active compound is the first dichlorinated benzodiazepine described to occur naturally in a tissue of mammals, not treated with benzodiazepines.

PMID:
3172979
[Indexed for MEDLINE]
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