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Eur J Immunol. 2019 Nov 14. doi: 10.1002/eji.201948314. [Epub ahead of print]

The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium.

Author information

1
Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
2
Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
3
Institute for Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
4
Systems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Abstract

Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.

KEYWORDS:

B cells; CD4+ T cells; Citrobacter rodentium; NF-κB; c-Rel

PMID:
31724737
DOI:
10.1002/eji.201948314

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