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Aging Male. 2019 Nov 14:1-10. doi: 10.1080/13685538.2019.1686756. [Epub ahead of print]

Aging and erectile function.

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Department of Reproductive Medicine, University of California San Diego, San Diego, CA, USA.
Reproductive Partners San Diego, La Jolla, CA, USA.
Diabetes, Education and Nutrition Department, Mercy Regional Medical Center, Durango, CO, USA.
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Department of Advanced Medical and Surgical Sciences, Diabetes Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.


The authors review and discuss numerous factors that influence erectile function and their interactions, based on the published literature. Of critical importance are vascular nitric oxide; nutrition; exercise; weight control and maintaining insulin sensitivity; early treatment of hypertension with attention to effects on erectile function; avoiding sources of oxidative stress such as obesity and smoking; reducing inflammation (e.g. from gingivitis); improving pelvic floor muscle strength; and inhibiting cyclic GMP break-down. The described interventions act on different aspects of erectile biochemistry and physiology. Therefore, combining multiple therapeutic approaches will yield maximum benefits for erectile and vascular and general health.


Erectile dysfunction; insulin resistance; nitric oxide; obesity; oxidative stress; pelvic floor exercises

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