In the present study five potent rhizobacterial antagonists of Fusarium oxysporum f. sp. ciceris alone and in combination with Mesorhizobium (M) were evaluated for their potential to elicit the defence response reactions to reduce the total loss of plants and enhance the growth of two chickpea cultivars i.e. resistant GPF-2 and susceptible JG-41. Observations revealed that maximum phenolic, peroxidase (PO) and polyphenol oxidase (PPO) activity was induced after 30th day of germination. Maximum phenol concentration of 745.8 and 724.1 μg/gfw root tissues was recorded by Ps45 when co-inoculated with Mesorhizobium in both the varieties i.e. GPF-2 and JG-41 respectively. Isolates Ps45, Ps47 and Ps44 were found most promising to induce PO and PPO activity, in combination with Mesorhizobium and recorded superior over the fungicide with respect to negative control. Similar results were recorded for the phenylalanine ammonia lyase (PAL), maximally induced on 20th day after germination, where dual inoculation of Ps44+M and Ps45+M induced 57.0 and 54.2 nmol of cinnamic acid min-1 gfw-1 in GPF-2. However in case of JG-41, Ps45 and Ba1a exhibited highest PAL activity of 54.2 and 41.4 nmol of cinnamic acid min-1 gfw-1. Malonic aldehyde concentration in stem tissues at 30th day revealed that lipid peroxidation was effectively reduced in rhizobacterial treated plants compared to fungicide and negative control, signifying the role of antagonistic plant growth promoting rhizobacteria in reducing the stress and enhancing the plant's defence response to reduce the disease incidence and thus improving the plant growth and yield. Moreover the dual inoculations were observed superior over the fungicide treatment as well as single inoculations in terms of growth (root/shoot length and weight), signifying the synergistic effect of screened antagonists and native Mesorhizobium in suppressing the pathogen and thereby enhancing the plant growth.