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Curr Top Med Chem. 2019 Nov 12. doi: 10.2174/1568026619666191112140939. [Epub ahead of print]

Feasibility of targeting glioblastoma stem cells: From concept to clinical trials.

Author information

1
Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russian Federation.
2
National Research University Higher School of Economics, 20 Myasnitskaya Street, Moscow, 101000, Russian Federation.
3
Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation.
4
Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow, 117418, Russian Federation.
5
Department of Biological Sciences, Salem University, Salem, WV, United States.

Abstract

Glioblastoma is a highly aggressive and invasive brain tumor. Current treatment options do not prolong overall survival significantly because the disease is highly prone to relapse. Therefore, research to find new therapies is of paramount importance. It was discovered that glioblastomas contain a population of cells with stem-like properties and that these cells are may be responsible for tumor recurrence. In this critical review, we will discuss potential treatment strategies to target cancer stem cells in glioblastoma with the focus on clinical perspectives. Several fundamental issues related to the research are highlighted as well.

KEYWORDS:

CAR T-cell therapy; Glioblastoma; brain tumor; cancer stem cells; molecular targeted therapy; stem cell self-renewal; vaccine therapy

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