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AIDS Behav. 2019 Nov 13. doi: 10.1007/s10461-019-02706-2. [Epub ahead of print]

Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis.

Author information

1
Division of Infectious Diseases and International Medicine, Department of Minnesota, University of Minnesota, 420 Delaware Street, SE, MMC 250, Minneapolis, MN, 55455, USA. Lofg0020@umn.edu.
2
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
3
Department of Psychiatry, Makerere University, Kampala, Uganda.
4
Division of Infectious Diseases and International Medicine, Department of Minnesota, University of Minnesota, 420 Delaware Street, SE, MMC 250, Minneapolis, MN, 55455, USA.

Abstract

Despite the substantial burden of HIV in Africa, and the knowledge that depression causes worse HIV outcomes, the burden of depression in people living with HIV in Africa is unknown. We searched Pubmed and four other databases using key terms: depression, Africa, HIV, and prevalence from 2008 to 2018. We summarized depression prevalence by country. We estimated the burden of depression using our prevalence data and 2018 UNAIDS HIV estimates. Our search yielded 70 articles across 16 African countries. The overall prevalence of major depression in those HIV-infected using a diagnostic interview was 15.3% (95% CI 12.5-17.1%). We estimate that 3.63 million (99.7% CI 3.15-4.19 million) individuals with HIV in Sub-Saharan Africa have major depression and provide country-level estimates. We estimate that 1.57 million (99.7% CI 1.37-1.82 million) DALYs are lost among people with depression and HIV in Sub-Saharan Africa. There is a significant burden of depression in Africans with HIV. Further work to screen for and treat depression in Sub-Saharan Africa is needed to improve HIV outcomes and achieve the 90-90-90 UNAIDS goals.

KEYWORDS:

Burden of disease; Depression; HIV; Prevalence; Sub-Saharan Africa

PMID:
31720956
DOI:
10.1007/s10461-019-02706-2

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