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Trends Parasitol. 2019 Nov 9. pii: S1471-4922(19)30247-8. doi: 10.1016/j.pt.2019.10.005. [Epub ahead of print]

New Strategies and Biomarkers for the Control of Visceral Leishmaniasis.

Author information

1
WHO Collaborating Centre for Leishmaniasis, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain.
2
WHO Collaborating Centre for Leishmaniasis, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain. Electronic address: javier.moreno@isciii.es.

Abstract

Effective diagnosis and treatment of visceral leishmaniasis, together with the study of vectors and reservoirs, can lead to a better understanding of the parasite transmission dynamics and the development of more efficient control measures. Recent studies have applied new methodologies and biomarkers, and these have contributed to the early and rapid diagnosis of the disease; assessment of success of pharmacological treatments; efficient monitoring of immunosuppressed individuals; and to population screening for field trials of vaccine efficacy. This opinion article proposes an update to the diagnostic tools for visceral leishmaniasis and their rational and combined use to establish the real prevalence of infection or of exposure to Leishmania in endemic areas.

KEYWORDS:

biomarkers; control; leishmaniasis; rapid diagnostic test

PMID:
31718888
DOI:
10.1016/j.pt.2019.10.005

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