Format

Send to

Choose Destination
Int J Mol Sci. 2019 Oct 25;20(21). pii: E5328. doi: 10.3390/ijms20215328.

PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers.

Author information

1
Institute of Orthopedics and Traumatology, School of Medicine, University of São Paulo (USP), São Paulo 05403-010, Brazil.
2
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
3
Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences (FCMSCSP), São Paulo 01221-020, Brazil.

Abstract

Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) are orthobiologic therapies considered as an alternative to the current therapies for muscle, bone and cartilage. Different formulations of biomaterials have been used as carriers for PRP and BMAC in order to increase regenerative processes. The most common biomaterials utilized in conjunction with PRP and BMAC clinical trials are organic scaffolds and natural or synthetic polymers. This review will cover the combinatorial strategies of biomaterial carriers with PRP and BMAC for musculoskeletal conditions (MsCs) repair and regeneration in clinical trials. The main objective is to review the therapeutic use of PRP and BMAC as a treatment option for muscle, bone and cartilage injuries.

KEYWORDS:

Platelet Rich Plasma (PRP); biomaterials; bone; bone marrow aspirate concentrate (BMAC); cartilage; muscle

PMID:
31717698
PMCID:
PMC6862231
DOI:
10.3390/ijms20215328
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center