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Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24334-24342. doi: 10.1073/pnas.1907982116. Epub 2019 Nov 11.

Accelerated evolution of oligodendrocytes in the human brain.

Author information

1
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
2
School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
3
Center for Medical Research and Education, Graduate School of Medicine, Osaka University, Suita, 565-0871 Osaka, Japan.
4
Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, 565-0871 Osaka, Japan.
5
Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 156-8506 Tokyo, Japan.
6
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
7
Division of Neuropharmacology and Neurologic Diseases, Emory University, Atlanta, GA 30329.
8
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
9
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329.
10
School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332; soojinyi@gatech.edu genevieve.konopka@utsouthwestern.edu.
11
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390; soojinyi@gatech.edu genevieve.konopka@utsouthwestern.edu.

Abstract

Recent discussions of human brain evolution have largely focused on increased neuron numbers and changes in their connectivity and expression. However, it is increasingly appreciated that oligodendrocytes play important roles in cognitive function and disease. Whether both cell types follow similar or distinctive evolutionary trajectories is not known. We examined the transcriptomes of neurons and oligodendrocytes in the frontal cortex of humans, chimpanzees, and rhesus macaques. We identified human-specific trajectories of gene expression in neurons and oligodendrocytes and show that both cell types exhibit human-specific up-regulation. Moreover, oligodendrocytes have undergone more pronounced accelerated gene expression evolution in the human lineage compared to neurons. We highlighted human-specific coexpression networks with specific functions. Our data suggest that oligodendrocyte human-specific networks are enriched for alternative splicing and transcriptional regulation. Oligodendrocyte networks are also enriched for variants associated with schizophrenia and other neuropsychiatric disorders. Such enrichments were not found in neuronal networks. These results offer a glimpse into the molecular mechanisms of oligodendrocytes during evolution and how such mechanisms are associated with neuropsychiatric disorders.

KEYWORDS:

brain evolution; cell-type expression; comparative primate genomics; neurogenomics

PMID:
31712436
PMCID:
PMC6883816
[Available on 2020-05-11]
DOI:
10.1073/pnas.1907982116

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