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Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1711-1718. doi: 10.2215/CJN.03110319. Epub 2019 Nov 11.

Change in Dyslipidemia with Declining Glomerular Filtration Rate and Increasing Proteinuria in Children with CKD.

Author information

1
Division of Pediatric Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York; Jeffrey.Saland@MSSM.edu.
2
Division of Pediatric Nephrology, Maimonides Medical Center, Brooklyn, New York.
3
Division of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
4
Department of Pediatrics, University of Washington, Seattle, Washington.
5
Division of Nephrology, Seattle Children's Hospital, Seattle, Washington.
6
Division of Pediatric Nephrology, Cincinnati Children's Hospital, Cincinnati, Ohio.
7
Division of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, Missouri.
8
Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and.
9
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Abstract

BACKGROUND AND OBJECTIVES:

Dyslipidemia, a risk factor for cardiovascular disease, is common in CKD but its change over time and how that change is influenced by concurrent progression of CKD have not been previously described.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:

In the CKD in Children study we prospectively followed children with progressive CKD and utilized multivariable, linear mixed-effects models to quantify the longitudinal relationship between within-subject changes in lipid measures (HDL cholesterol, non-HDL cholesterol, triglycerides) and within-subject changes in GFR, proteinuria, and body mass index (BMI).

RESULTS:

A total of 508 children (76% nonglomerular CKD, 24% glomerular CKD) had 2-6 lipid measurements each, with a median follow-up time of 4 (interquartile range [IQR], 2.1-6.0) years. Among children with nonglomerular CKD, dyslipidemia was common at baseline (35%) and increased significantly as children aged; 43% of children with glomerular CKD had dyslipidemia at baseline and demonstrated persistent levels as they aged. Longitudinal increases in proteinuria were independently associated with significant concomitant increases in non-HDL cholesterol (nonglomerular: 4.9 [IQR, 3.4-6.4] mg/dl; glomerular: 8.5 [IQR, 6.0-11.1] mg/dl) and triglycerides (nonglomerular: 3% [IQR, 0.8%-6%]; glomerular: 5% [IQR, 0.6%-9%]). Decreases in GFR over follow-up were significantly associated with concomitant decreases of HDL cholesterol in children with nonglomerular CKD (-1.2 mg/dl; IQR, -2.1 to -0.4 mg/dl) and increases of non-HDL cholesterol in children with glomerular CKD (3.9 mg/dl; IQR, 1.4-6.5 mg/dl). The effects of increased BMI also affected multiple lipid changes over time. Collectively, glomerular CKD displayed stronger, deleterious associations between within-subject change in non-HDL cholesterol (9 mg/dl versus 1.2 mg/dl; P<0.001) and triglycerides (14% versus 3%; P=0.004), and within-subject change in BMI; similar but quantitatively smaller differences between the two types of CKD were noted for associations of within-subject change in lipids to within-subject change in GFR and proteinuria.

CONCLUSIONS:

Dyslipidemia is a common and persistent complication in children with CKD and it worsens in proportion to declining GFR, worsening proteinuria, and increasing BMI.

KEYWORDS:

HDL cholesterol; HDL lipoproteins; body mass; cardiovascular disease; cardiovascular diseases; child; cholesterol; chronic kidney disease; chronic renal insufficiency; dyslipidemia; dyslipidemias; follow-up studies; glomerular filtration rate; humans; lipids; pediatric nephrology; proteinuria; risk factors; triglycerides

PMID:
31712386
PMCID:
PMC6895497
[Available on 2020-12-06]
DOI:
10.2215/CJN.03110319

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