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Stem Cell Res. 2019 Nov 4;41:101640. doi: 10.1016/j.scr.2019.101640. [Epub ahead of print]

Generation of 5 hiPSC lines derived from three unrelated idiopathic Parkinson disease patients and two unrelated healthy control individuals.

Author information

1
National Laboratory for Embryonic Stem Cells (LaNCE), Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, SP 05508-900, Brazil.
2
Movement Disorders Clinic Division of Neurology, Hospital das Clínicas, Faculty of Medicine, Universidade de São Paulo (HC-FMUSP), Brazil.
3
National Laboratory for Embryonic Stem Cells (LaNCE), Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, SP 05508-900, Brazil. Electronic address: lpereira@usp.br.

Abstract

We describe generation of human induced pluripotent stem cell (hiPSC) lines of three unrelated idiopathic late onset Parkinson disease patients and two healthy controls above 60 years of age without neurological diseases nor Ashkenazi ancestry. Human iPSC were derived from peripheral blood-erythroblasts using integration free episomal plasmids carrying four reprogramming factors OCT4, SOX2, c-MYC, KLF4 and BCL-XL. The hiPSC lines were characterized according to established criteria.

PMID:
31710912
DOI:
10.1016/j.scr.2019.101640
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