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Int J Fertil Steril. 2020 Jan;13(4):277-281. doi: 10.22074/ijfs.2020.5466. Epub 2019 Nov 11.

A Comparison of Postpartum Depression in Mothers Conceived by Assisted Reproductive Technology and Those Naturally Conceived.

Author information

1
Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
2
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
3
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.Electronic Address: f.malekzadeh@royaninstitute.org.
4
Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
5
Department of Biostatistics and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
6
Department of Medical Education, School of Medicine and Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Tehran, Iran.

Abstract

Background:

It is thought that mothers who conceive via assisted reproductive technology (ART) may be at greater risk of postpartum depression (PPD) because of the problems and psychological stresses associated with ART treatment. The aim of the present study is to determine the occurrence of PPD among mothers who conceive by ART in comparison with those who naturally conceive. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD.

Materials and Methods:

This historical cohort study investigated 406 mothers with infants aged 3-9 months. Three hundred and eight women with natural pregnancies were selected as the control group from mothers who referred to Tehran healthcare centres for infant vaccinations. The ART group consisted of 98 women who conceived via ART at Royan Institute. Participants completed a general questionnaire that asked about education, occupation, number of children, delivery method, history of infant hospitalization, breastfeeding, mothers' and infants' ages, cause of infertility (ART group), and history of depression. A validated Persian version of the EPDS was used to measure depressive symptoms.

Results:

The mean EPDS score in mothers who naturally conceived was 8.38 ± 0.35 in comparison with mothers who conceived via ART (7.59 ± 0.63). The proportions of women who reported PPD were 26.0% for the control group and 20.4% for the ART group. There was no statistically significant difference in PPD between the control and ART groups (P=0.26).

Conclusion:

The occurrence of PPD in mothers who conceived via ART was similar to those who conceived naturally.

KEYWORDS:

Assisted Reproductive Technology; Edinburgh Postnatal Depression Scale; Natural Pregnancy; Postpartumn Depression

PMID:
31710187
PMCID:
PMC6875850
[Available on 2020-01-01]
DOI:
10.22074/ijfs.2020.5466

Conflict of interest statement

The authors declare no conflicts of interest.

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