Format

Send to

Choose Destination
Front Pediatr. 2019 Oct 24;7:436. doi: 10.3389/fped.2019.00436. eCollection 2019.

The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT.

Author information

1
Division for Pediatric Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt, Germany.
2
Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah Medical Center, Jerusalem, Israel.
3
Department of Immunology, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
4
Graduate Research School, University of New South Wales, Kensington, NSW, Australia.

Abstract

Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.

KEYWORDS:

granulocyte colony-stimulating factor; hematopoietic stem cell transplantation; leukemia; neutropenia; neutrophils

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center