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Intern Med. 2019 Nov 8. doi: 10.2169/internalmedicine.3865-19. [Epub ahead of print]

Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus.

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Department of Gastroenterology, Aichi Medical University School of Medicine, Japan.
Department of Surgical Pathology, Aichi Medical University School of Medicine, Japan.


We experienced marked efficacy with steroid treatment of three patients with jackhammer esophagus (JHE). An esophageal biopsy revealed eosinophilic esophagitis (EoE) in two patients. One of the patients without EoE had eosinophilia and an increased serum immunoglobulin E level, and endoscopic ultrasonography revealed thickening of the esophageal muscularis propria. Esophageal manometry was used to diagnose all cases of JHE. Treatment consisted of steroid administration, which improved the symptoms and resolved the esophageal muscularis propria thickening in all patients. The esophageal manometry findings also normalized following treatment. Allergic diseases, including EoE, were assumed to have caused JHE.


Jackhammer esophagus; eosinophilic esophagitis; gastroesophageal reflux disease; high-resolution manometry; prednisolone

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