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Card Electrophysiol Clin. 2019 Dec;11(4):563-571. doi: 10.1016/j.ccep.2019.08.007.

New Findings in Atrial Fibrillation Mechanisms.

Author information

1
Department of Cardiology, Centre for Heart Rhythm Disorders, University of Adelaide, Royal Adelaide Hospital, 1 Port Road, Adelaide, South Australia 5000, Australia.
2
Department of Cardiology, Centre for Heart Rhythm Disorders, University of Adelaide, Royal Adelaide Hospital, 1 Port Road, Adelaide, South Australia 5000, Australia. Electronic address: prash.sanders@adelaide.edu.au.

Abstract

This review focusses on novel findings in atrial fibrillation mechanisms derived from mapping studies. Recent panoramic mapping techniques have identified 2 arrhythmic mechanisms of interest, namely, rotational (rotors) and ectopic focal activations as drivers of atrial fibrillation. Epicardial adipose tissue and fatty infiltration into the myocardium have been described as novel substrates for atrial fibrillation. There is increasing appreciation that the thin atrial walls harbor a complex 3-dimensional electrostructural substrate to contribute to atrial fibrillation sustenance. Further research is warranted to advance the field toward more targeted therapy.

KEYWORDS:

Atrial fibrillation; Catheter ablation; Drivers; Mechanism; Remodeling

PMID:
31706465
DOI:
10.1016/j.ccep.2019.08.007

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