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J Mol Biol. 2019 Nov 6. pii: S0022-2836(19)30623-0. doi: 10.1016/j.jmb.2019.10.027. [Epub ahead of print]

Autophagosome Biogenesis Machinery.

Author information

1
Signalling Programme, Babraham Institute, Cambridge, UK.
2
Signalling Programme, Babraham Institute, Cambridge, UK. Electronic address: nicholas.ktistakis@babraham.ac.uk.

Abstract

We review current knowledge of the process of autophagosome formation with special emphasis on the very early steps: turning on the autophagy pathway, assembling the autophagy machinery, and building the autophagosome. The pathway is remarkably well coordinated spatially and temporally, and it shows broad conservation across species and cell types, including neurons. In addition, although much current knowledge derives mostly from settings of nonselective autophagy, recent work also indicates that selective autophagy, and more specifically mitophagy, shows similar dynamics. Having an understanding of this remarkable process may help the design of novel therapeutics for neurodegeneration and other pathologies.

KEYWORDS:

Autophagosomes; Mitophagy; ULK complex; VPS34 complex; mTOR

PMID:
31705882
DOI:
10.1016/j.jmb.2019.10.027

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