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Toxicol Lett. 2019 Nov 4;319:168-174. doi: 10.1016/j.toxlet.2019.10.026. [Epub ahead of print]

Long-term Respiratory Effects of Mustard Vesicants.

Author information

1
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
2
Environmental and Occupational Health, School of Public Health, Rutgers University, Piscataway, NJ, USA.
3
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA. Electronic address: laskin@eohsi.rutgers.edu.

Abstract

Sulfur mustard and related vesicants are cytotoxic alkylating agents that cause severe damage to the respiratory tract. Injury is progressive leading, over time, to asthma, bronchitis, bronchiectasis, airway stenosis, and pulmonary fibrosis. As there are no specific therapeutics available for victims of mustard gas poisoning, current clinical treatments mostly provide only symptomatic relief. In this article, the long-term effects of mustards on the respiratory tract are described in humans and experimental animal models in an effort to define cellular and molecular mechanisms contributing to lung injury and disease pathogenesis. A better understanding of mechanisms underlying pulmonary toxicity induced by mustards may help in identifying potential targets for the development of effective clinical therapeutics aimed at mitigating their adverse effects.

KEYWORDS:

Lung injury; Mustard vesicant; Pulmonary fibrosis

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