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Exp Cell Res. 2019 Nov 5:111712. doi: 10.1016/j.yexcr.2019.111712. [Epub ahead of print]

GP130 signaling and the control of naïve pluripotency in humans, monkeys, and pigs.

Author information

1
Univ Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500, Bron, France. Electronic address: pierre-yves.bourillot@inserm.fr.
2
Univ Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500, Bron, France.
3
CRTI, UNIV Nantes, INSERM, Nantes, France; ITUN, CHU Nantes, Nantes, France; SFR-SANTE, iPSC core facility, UNIV Nantes, INSERM, CNRS, CHU, Nantes, Nantes, France.

Abstract

The leukemia inhibitory factor (LIF)/glycoprotein (GP) 130/Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 signaling pathway is a hallmark of naïve pluripotency in mice. In this review, we discuss the role of the LIF/GP130/JAK/STAT3 pathway in supporting the naïve-state pluripotency in human, monkey, and pig pluripotent stem cells (PSCs). We highlight the role of LIF/GP130/JAK/STAT3 signaling in reprogramming conventional human and monkey PSCs to naïve-like pluripotency. We analyze published single-cell RNA sequencing datasets of human and monkey embryos and note that the main components of the GP130/JAK/STAT3 pathway are expressed in pluripotent cells at preimplantation stages. We conclude that there is a growing body of evidence supporting the involvement of GP130/JAK/STAT3 in the regulation of naïve pluripotency in non-rodent species including humans, monkeys, and pigs.

KEYWORDS:

Human; Leukemia inhibitory factor; Monkey; Pig; Pluripotency; STAT3; Stem cells

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