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Neuron. 2019 Nov 6;104(3):431-432. doi: 10.1016/j.neuron.2019.10.029.

Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem.

Author information

1
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: lester@caltech.edu.
2
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

In this issue of Neuron, Gharpure et al. (2019) nearly complete atomic-level descriptions for binding, permeation, and subunit interactions at the two major heteropentameric nicotinic receptors-those governing nicotine's rewarding and aversive effects. Can we finally design highly selective and useful nicotinic drugs?

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