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Ocul Immunol Inflamm. 2019 Nov 7:1-7. doi: 10.1080/09273948.2019.1678651. [Epub ahead of print]

Causes of Hypertensive Anterior Uveitis in Thailand.

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Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, the Netherlands.


Purpose: To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor.Methods: Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (CMV), herpes simplex (HSV), varicella-zoster (VZV), rubella, chikungunya and Zika virus.Results: The prevalence of PCR-positive results was 32%, including 19% for CMV, 10% for HSV, and 3% for VZV; PCR for other tested viruses demonstrated negative results. PCR-positive patients exhibited satisfactory IOP control with antiviral and anti-glaucomatous treatment compared to PCR-negative patients, and more than half of PCR-negative patients required glaucoma surgery within 12 months (P = .01).Conclusion: PCR evidence of infection with herpes group viruses was found in one-third of patients with hypertensive anterior uveitis; CMV being the most common pathogen. The PCR-positive group generally responded well to a combination of antiviral and anti-glaucoma treatment.


Cytomegalovirus; herpes simplex virus; hypertensive anterior uveitis; polymerase chain reaction; varicella-zoster virus

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