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Ocul Immunol Inflamm. 2019 Nov 7:1-7. doi: 10.1080/09273948.2019.1678651. [Epub ahead of print]

Causes of Hypertensive Anterior Uveitis in Thailand.

Author information

1
Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
2
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
3
Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
4
Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, the Netherlands.

Abstract

Purpose: To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor.Methods: Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (CMV), herpes simplex (HSV), varicella-zoster (VZV), rubella, chikungunya and Zika virus.Results: The prevalence of PCR-positive results was 32%, including 19% for CMV, 10% for HSV, and 3% for VZV; PCR for other tested viruses demonstrated negative results. PCR-positive patients exhibited satisfactory IOP control with antiviral and anti-glaucomatous treatment compared to PCR-negative patients, and more than half of PCR-negative patients required glaucoma surgery within 12 months (P = .01).Conclusion: PCR evidence of infection with herpes group viruses was found in one-third of patients with hypertensive anterior uveitis; CMV being the most common pathogen. The PCR-positive group generally responded well to a combination of antiviral and anti-glaucoma treatment.

KEYWORDS:

Cytomegalovirus; herpes simplex virus; hypertensive anterior uveitis; polymerase chain reaction; varicella-zoster virus

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