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Org Lett. 2019 Nov 7. doi: 10.1021/acs.orglett.9b03778. [Epub ahead of print]

Total Synthesis of (+)-Jatrophalactam.

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Department of Chemistry , Zhejiang University , Hangzhou 310058 , China.
Department of Applied Chemistry , Zhejiang Gongshang University , Hangzhou 310018 , China.


The first asymmetric total synthesis of (+)-jatrophalactam was reported, which unambiguously determined the absolute configuration of the titled natural product. The key features entail a conformationally controlled cyclopropanation, a Meldrum's acid adduct-engaged macrolactam formation, and a Pd(II)-mediated oxidative cyclization.

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