Incidence and prognosis of clinically significant incidental prostate cancer after radical cystectomy for bladder cancer

Arch Esp Urol. 2019 Nov;72(9):915-920.
[Article in English, Spanish]

Abstract

Objective: To evaluate the prevalence and significance of incidental prostate cancer in patients after radical cystectomy for bladder cancer, as well as its impact in terms of overall survival and biochemical recurrence.

Methods: Patients with bladder cancer treated with radical cystectomy in our hospital between 1998 and 2014 were included in the study. None of the patients had previous history of prostatic adenocarcinoma. Complete embedding of the prostate gland as whole mount serial section of the radical cystectomy specimens was done.

Results: 180 patients were included. The mean age was 69.71 years with a median follow-up of 34.2 months. Three groups were analyzed: non-incidental prostate cancer (n=136), non-significant incidental prostate cancer (n=28) and significant incidental prostate cancer (n=16). During follow-up, 50 patients (27.78%) died from bladder cancer. There were no differences in overall survival between patients with or without prostate cancer, neither between patients with significant nor insignificant prostate cancer in the radical cystectomy specimens. Biochemical recurrence was not observed in any patient.

Conclusions: Incidental prostate cancer had a higher prevalence than previously expected in our cohort (24.4%), but it had no impact in overall survival of patients not even in those with a significant prostate cancer. No biochemical recurrence was reported during the study.

Objetivo: Evaluar la prevalencia y el pronóstico del cáncer de próstata incidental en pacientes tras cistectomía radical con cáncer vesical, así como su impacto en la supervivencia global y la recidiva bioquímica en su seguimiento.

Metodo: Se analizan pacientes con cáncer vesical tratados con cistectomía radical en nuestro hospital entre los años 1998 y 2014, sin presentar ninguno de ellos antecedentes de cáncer de próstata. Se dividen los pacientes según no presenten cáncer de próstata, éste sea no significativo clínicamente o significativo clínicamente y se compara su pronóstico entre ellos.

Resultados: Se incluyen 180 pacientes en el análisis con una edad media de 69,7 años y una mediana de seguimiento de 34,2 meses. Entre los grupos: 136 no presentaban cáncer de próstata, 28 lo presentaban no significativo y 16 clínicamente significativo. Durante el seguimiento, 50 (27,8%) fallecieron por su cáncer vesical. No se encontraron diferencias entre los grupos en términos de supervivencia global, además no se objetivó ningún caso de recidiva bioquímica entre los pacientes con cáncer de próstata.

Conclusion: El cáncer de próstata incidental tiene una prevalencia más alta de lo esperado en nuestra serie (24,4%), aunque su presencia no impacta en la supervivencia global de los pacientes, incluso aunque sea clínicamente significativo. No hubo ningún caso de recidiva bioquímica durante el seguimiento.

Keywords: Bladder cancer; Cistectomía; Cystectomy; Cáncer de próstata; Cáncer vesical; Prostate cancer.

MeSH terms

  • Aged
  • Cystectomy*
  • Humans
  • Incidence
  • Incidental Findings
  • Male
  • Prognosis
  • Prostatectomy
  • Prostatic Neoplasms* / diagnosis
  • Retrospective Studies
  • Urinary Bladder Neoplasms* / surgery