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AIDS Behav. 2019 Nov 6. doi: 10.1007/s10461-019-02715-1. [Epub ahead of print]

Efficacy is Not Everything: Eliciting Women's Preferences for a Vaginal HIV Prevention Product Using a Discrete-Choice Experiment.

Author information

1
Women's Global Health Imperative, RTI International, 351 California Street, Suite 500, San Francisco, CA, 94104, USA. ebrowne@rti.org.
2
Women's Global Health Imperative, RTI International, 351 California Street, Suite 500, San Francisco, CA, 94104, USA.
3
Health Solutions, RTI International, Research Triangle Park, NC, USA.
4
MatCH Research Unit (MRU), Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa.
5
CONRAD, Eastern Virginia Medical School, Arlington, VA, USA.
6
University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe.
7
Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, CA, USA.

Abstract

As new female-initiated HIV prevention products enter development, it is crucial to incorporate women's preferences to ensure products will be desired, accepted, and used. A discrete-choice experiment was designed to assess the relative importance of six attributes to stated choice of a vaginally delivered HIV prevention product. Sexually active women in South Africa and Zimbabwe aged 18-30 were recruited from two samples: product-experienced women from a randomized trial of four vaginal placebo forms and product-naïve community members. In a tablet-administered survey, 395 women chose between two hypothetical products over eight choice sets. Efficacy was the most important, but there were identifiable preferences among other attributes. Women preferred a product that also prevented pregnancy and caused some wetness (p < 0.001). They disliked a daily-use product (p = 0.002) and insertion by finger (p = 0.002). Although efficacy drove preference, wetness, pregnancy prevention, and dosing regimen were influential to stated choice of a product, and women were willing to trade some level of efficacy to have other more desired attributes.

KEYWORDS:

Discrete-choice experiment; HIV prevention; South Africa; Women; Zimbabwe

PMID:
31696371
DOI:
10.1007/s10461-019-02715-1

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