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Lipids Health Dis. 2019 Nov 6;18(1):194. doi: 10.1186/s12944-019-1143-z.

Omega-3 polyunsaturated fatty acids status and cognitive function in young women.

Author information

1
Faculty of Health Sciences, Discipline of Exercise and Sport Science, The University of Sydney, PO Box 170, Lidcombe, NSW, 1825, Australia.
2
Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.
3
School of Exercise Science, Sport and Health, Charles Sturt University, Bathurst, NSW, Australia.
4
Academic Department of Adolescent Medicine, The Children's Hospital at Westmead, Westmead, NSW, Australia.
5
Faculty of Medicine and Health, Sydney Medical School, Discipline of Child and Adolescent Health, The University of Sydney, Westmead, NSW, Australia.
6
Metabolism and Obesity Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
7
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
8
Faculty of Health Sciences, Discipline of Exercise and Sport Science, The University of Sydney, PO Box 170, Lidcombe, NSW, 1825, Australia. helen.oconnor@sydney.edu.au.
9
Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia. helen.oconnor@sydney.edu.au.

Abstract

BACKGROUND:

Research indicates that low omega-3 polyunsaturated fatty acid (n-3 PUFA) may be associated with decreased cognitive function. This study examined the association between n-3 PUFA status and cognitive function in young Australian women.

METHODS:

This was a secondary outcome analysis of a cross-sectional study that recruited 300 healthy women (18-35 y) of normal weight (NW: BMI 18.5-24.9 kg/m2) or obese weight (OB: BMI ≥30.0 kg/m2). Participants completed a computer-based cognition testing battery (IntegNeuro™) evaluating the domains of impulsivity, attention, information processing, memory and executive function. The Omega-3 Index (O3I) was used to determine n-3 PUFA status (percentage of EPA (20:5n-3) plus DHA (22:6n3) in the red cell membrane) and the participants were divided into O3I tertile groups: T1 < 5.47%, T2 = 5.47-6.75%, T3 > 6.75%. Potential confounding factors of BMI, inflammatory status (C-reactive Protein), physical activity (total MET-min/wk), alpha1-acid glycoprotein, serum ferritin and hemoglobin, were assessed. Data reported as z-scores (mean ± SD), analyses via ANOVA and ANCOVA.

RESULTS:

Two hundred ninety-nine women (26.9 ± 5.4 y) completed the study (O3I data, n = 288). The ANOVA showed no overall group differences but a significant group × cognition domain interaction (p < 0.01). Post hoc tests showed that participants in the low O3I tertile group scored significantly lower on attention than the middle group (p = 0.01; ES = 0.45 [0.15-0.74]), while the difference with the high group was borderline significant (p = 0.052; ES = 0.38 [0.09-0.68]). After confounder adjustments, the low group had lower attention scores than both the middle (p = 0.01) and high (p = 0.048) groups. These findings were supported by univariate analyses which found significant group differences for the attention domain only (p = 0.004).

CONCLUSIONS:

Cognitive function in the attention domain was lower in women with lower O3I, but still within normal range. This reduced but normal level of cognition potentially provides a lower baseline from which cognition would decline with age. Further investigation of individuals with low n-3 PUFA status is warranted.

KEYWORDS:

Attention; Cognition; N-3 PUFA; Omega-3; Women

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