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Fertil Steril. 1988 Oct;50(4):630-4.

Dynamics of estradiol and testosterone and seminal fluid indexes in smokers and nonsmokers.

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1
Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.

Abstract

The serum levels of estradiol (E2) and testosterone (T), the metabolic clearance rates of estradiol (MCRE2) and testosterone (MCRT), and the production rates of estradiol and testosterone (PRE2) and (PRT) were examined in 22 male smokers and 21 male nonsmokers. Seminal fluid indexes (sperm count, % motility, grade of motility, and % of sperm with abnormal morphology) were also assessed. The mean E2 level and the mean PRE2 were significantly greater in smokers than in nonsmokers (P less than 0.001 and P less than 0.01, respectively); however, the means of MCRE2, MCRT, PRT, and T did not differ significantly in smokers compared to nonsmokers. No significant product-moment correlations were found between the various hormonal measures and the seminal fluid indexes in the overall sample. However, the smokers with sperm counts below the median sperm count of the sample had significantly higher mean levels of E2 and PRE2 than did the smokers with sperm counts above that median. Mechanisms that might mediate the greater PRE2 of smokers and a negative relationship between estradiol and sperm count are discussed.

PIP:

Serum levels of estradiol (E2) and testosterone (T), the metabolic clearance rates of estradiol (MCRE2) and testosterone (MCRT), and the production rates of estradiol (PRE2) and testosterone (PRT) were examined in 22 male smokers and 21 male nonsmokers recruited from local colleges. Also assessed were seminal fluid indexes. The mean E2 level of smokers (36.7 + or - 14.3 pg/ml) was significantly higher than that of nonsmokers (24.6 + or - 7.0 pg/ml) (p0.001); the mean PRE2 was also significantly higher among smokers (48.3 + or - 18.5 mcg/24 hours) than nonsmokers (34.1 + or - 14.0 mcg/24 hours) (p0.01). Although smokers had a significantly higher mean MCRT than nonsmokers, this difference was no longer significant when corrections were made for body surface area. There were no significant differences between T, PRT, or MCRE2 of the smokers and nonsmokers. No significant product-moment correlations were found between the various hormonal measures and the seminal fluid indexes in the overall sample. However, smokers with sperm counts below the median of the sample had significantly higher mean levels of E2 and PRE2 than smokers with sperm counts above the mean. The number of cigarettes smoked or the duration of smoking did not relate significantly to the E2 levels, PRE2, or the seminal fluid indexes. The mechanism by which cigarette smoking induces an increased PRE2 is unknown. However, it is hypothesized that, by increasing blood catecholamine levels, smoking may increase the conversion of testosterone to estradiol, via aromatization in peripheral tissues, thereby increasing the production rate and, secondarily, the serum level of estradiol.

PMID:
3169284
[Indexed for MEDLINE]
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