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FEBS Lett. 1988 Oct 10;238(2):343-6.

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.

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1
Laboratoire de Biochimie, CNRS URA 84, Faculté de Médecine, Reims, France.

Abstract

Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide with affinity for copper(II) ions and was isolated from human plasma. This peptide appears to play a physiological role in wound healing. We report the stimulating effect of GHK-Cu on collagen synthesis by fibroblasts. The stimulation began between 10(-12) and 10(-11) M, maximized at 10(-9) M, and was independent of any change in cell number. The presence of a GHK triplet in the alpha 2(I) chain of type I collagen suggests that the tripeptide might be liberated by proteases at the site of a wound and exert in situ healing effects.

PMID:
3169264
DOI:
10.1016/0014-5793(88)80509-x
[Indexed for MEDLINE]
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