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Curr Drug Deliv. 2019 Nov 5. doi: 10.2174/1567201816666191106102740. [Epub ahead of print]

Release Kinetics of Nicotine Loaded onto Mesoporous Silicate Materials for Use in Nicotine Replacement Therapy.

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Department of Chemistry, The University of Jordan, Amman 11942. Jordan.


In this work, loading of nicotine onto mesoporous silicate materials and its release into a phosphate buffer solution at 37°C were investigated. The mesoporous silicate materials designated as MCM-41 were prepared with different pore sizes via using alkyltrimethylammonium bromide surfactants with different alkyl chain lengths of carbon atoms 12, 14, and 16. The mesoporous silicate systems were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), N2-adsorption-desorption isotherms and FT-IR spectroscopy. Loading of nicotine was confirmed by FTIR and thermal gravimetric analysis and was determined by high performance liquid chromatography (HPLC). A slight increase in loading capacity with increasing pore size was observed, with a loading capacity of about 17% for MCM-41(16). Release of nicotine was monitored by HPLC and was almost complete for MCM-41(14) and MCM-41(16) in 8 h.


Drug delivery; HPLC; MCM-41; Mesoporous materials; Nicotine

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