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Curr Pharm Des. 2019;25(40):4274-4286. doi: 10.2174/1381612825666191105125148.

Application of Genome-Wide Association Studies in Coronary Artery Disease.

Zheng H1,2,3, Zeng Z2,3,4, Wen H2,3,5, Wang P1, Huang C1, Huang P1, Chen Q1, Gong D2,3,4, Qiu X6,2,3.

Author information

1
Department of Medical Examination & Health Management, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
2
Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Nanning, Guangxi, China.
3
Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, Guangxi, China.
4
Elderly Cardiology Ward, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
5
Elderly Comprehensive Ward, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
6
Department of Population Health Science, Duke University School of Medicine, Durham, North Carolina, NC27708, United States.

Abstract

Coronary artery disease (CAD) is a complex disease caused by the combination of environmental and genetic factors. It is one of the leading causes of death and disability in the world. Much research has been focussed on CAD genetic mechanism. In recent years, genome-wide association study (GWAS) has developed rapidly around the world. Medical researchers around the world have successfully discovered a series of CAD genetic susceptibility genes or susceptible loci using medical research strategies, leading CAD research toward a new stage. This paper briefly summarizes the important progress made by GWAS for CAD in the world in recent years, and then analyzes the challenges faced by GWAS at this stage and the development trend of future research, to promote the transformation of genetic research results into clinical practice and provide guidance for further exploration of the genetic mechanism of CAD.

KEYWORDS:

Genome-wide association study; coronary artery disease; genetic factors; genetic mechanism; genetic susceptibility locus; single nucleotide polymorphism.

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