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Brain Topogr. 2020 Jan;33(1):123-134. doi: 10.1007/s10548-019-00741-9. Epub 2019 Nov 6.

Finger Tapping Task Activation vs. TMS Hotspot: Different Locations and Networks.

Wang J1, Meng HJ1, Ji GJ2,3, Jing Y4,5,6, Wang HX4,5,6, Deng XP4,5,6, Feng ZJ4,5,6, Zhao N4,5,6, Zang YF7,8,9, Zhang J10.

Author information

1
School of Psychology, Shanghai University of Sport, Shanghai, 200438, China.
2
Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, 230032, China.
3
Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, 230032, Anhui, China.
4
Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
5
Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, 311121, China.
6
Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, 310015, China.
7
Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, 311121, China. zangyf@hznu.edu.cn.
8
Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, 311121, China. zangyf@hznu.edu.cn.
9
Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, 310015, China. zangyf@hznu.edu.cn.
10
School of Psychology, Shanghai University of Sport, Shanghai, 200438, China. zhangjian@sus.edu.cn.

Abstract

Both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) have been used to non-invasively localize the human motor functional area. These locations can be clinically used as stimulation target of TMS treatment. However, it has been reported that the finger tapping fMRI activation and TMS hotspot were not well-overlapped. The aim of the current study was to measure the distance between the finger tapping fMRI activation and the TMS hotspot, and more importantly, to compare the network difference by using resting-state fMRI. Thirty healthy participants underwent resting-state fMRI, task fMRI, and then TMS hotspot localization. We found significant difference of locations between finger tapping fMRI activation and TMS hotspot. Specifically, the finger tapping fMRI activation was more lateral than the TMS hotspot in the premotor area. The fMRI activation peak and TMS hotspot were taken as seeds for resting-state functional connectivity analyses. Compared with TMS hotspot, finger tapping fMRI activation peak showed more intensive functional connectivity with, e.g., the bilateral premotor, insula, putamen, and right globus pallidus. The findings more intensive networks of finger tapping activation than TMS hotspot suggest that TMS treatment targeting on the fMRI activation area might result in more remote effects and would be more helpful for TMS treatment on movement disorders.

KEYWORDS:

Finger tapping fMRI activation; Hotspot; Resting-state functional connectivity; TMS

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