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Perit Dial Int. 2019 Nov-Dec;39(6):570-573. doi: 10.3747/pdi.2019.00041.

Long-Term Clinical Outcomes of Lupus Nephritis Patients Undergoing Peritoneal Dialysis: A Matched, Case-Control Study.

Ye H1,2, Cao P1,2, Lin J1,2, Yang X1,2, Guo Q1,2, Mao H1,2, Yu X1,3, Chen W4,2.

Author information

1
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
2
Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou, China.
3
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
4
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China vvchen66@qq.com.

Abstract

The long-term clinical outcomes of peritoneal dialysis (PD) for patients with lupus nephritis (LN) have not been well researched. In the present study, we investigated the long-term prognosis of a Chinese PD cohort. This was a retrospective case-control study that included LN patients receiving PD treatment for more than 90 days from January 2006 to December 2012. Non-diabetic control patients were selected using a ratio of 1:2 for age- and gender-matching. The primary outcome was all-cause mortality. Secondary outcomes included technique failure and hospitalization rate. All patients were followed up to 31 December 2017. A total of 28 LN patients on PD (89.3% female, mean age 42.2±15.8 years) and 56 controls were included. After a median follow-up period of 53.1 months, 11 LN patients died. The cumulative 1-, 3-, and 5-year patient survival rates were 92.4%, 84.7%, and 67.6% in LN patients, and 100%, 93.5%, and 82.9% in the control group, respectively (p = 0.035). After adjusting for confounders, LN was not significantly associated with mortality (hazard ratio [HR]: 1.39, 95% confidence interval [CI]: 0.45 - 4.26); However, LN was still an independent risk factor of technique failure (HR: 2.87, 95% CI: 1.08 - 7.66). Meanwhile, the LN group had significantly higher hospitalization and infection rates. In conclusion, LN patients undergoing PD had poor patient survival and technique survival, and higher hospitalization and infection rates.

KEYWORDS:

Hospitalization; peritonitis; survival; technique survival

PMID:
31690702
DOI:
10.3747/pdi.2019.00041

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