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Perit Dial Int. 2019 Nov-Dec;39(6):570-573. doi: 10.3747/pdi.2019.00041.

Long-Term Clinical Outcomes of Lupus Nephritis Patients Undergoing Peritoneal Dialysis: A Matched, Case-Control Study.

Ye H1,2, Cao P1,2, Lin J1,2, Yang X1,2, Guo Q1,2, Mao H1,2, Yu X1,3, Chen W4,2.

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Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou, China.
Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China


The long-term clinical outcomes of peritoneal dialysis (PD) for patients with lupus nephritis (LN) have not been well researched. In the present study, we investigated the long-term prognosis of a Chinese PD cohort. This was a retrospective case-control study that included LN patients receiving PD treatment for more than 90 days from January 2006 to December 2012. Non-diabetic control patients were selected using a ratio of 1:2 for age- and gender-matching. The primary outcome was all-cause mortality. Secondary outcomes included technique failure and hospitalization rate. All patients were followed up to 31 December 2017. A total of 28 LN patients on PD (89.3% female, mean age 42.2±15.8 years) and 56 controls were included. After a median follow-up period of 53.1 months, 11 LN patients died. The cumulative 1-, 3-, and 5-year patient survival rates were 92.4%, 84.7%, and 67.6% in LN patients, and 100%, 93.5%, and 82.9% in the control group, respectively (p = 0.035). After adjusting for confounders, LN was not significantly associated with mortality (hazard ratio [HR]: 1.39, 95% confidence interval [CI]: 0.45 - 4.26); However, LN was still an independent risk factor of technique failure (HR: 2.87, 95% CI: 1.08 - 7.66). Meanwhile, the LN group had significantly higher hospitalization and infection rates. In conclusion, LN patients undergoing PD had poor patient survival and technique survival, and higher hospitalization and infection rates.


Hospitalization; peritonitis; survival; technique survival


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