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Lipids Health Dis. 2019 Nov 5;18(1):193. doi: 10.1186/s12944-019-1139-8.

Parenteral systems for statin delivery: a review.

Author information

1
Research center of oils and fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2
Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Nanotechnology Research Center, Buali (Avicenna) Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland.
5
Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
6
Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.
7
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
8
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran. sahebkara@mums.ac.ir.
9
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
10
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran. sahebkara@mums.ac.ir.

Abstract

The oral route of drug administration is the most common and convenient route for dosing statin drugs, and, in fact, most medications, because of ease of drug delivery, patient compliance, and cost-effectiveness. However, the oral administration of statin drugs has disadvantages such as hepatic first-pass metabolism and degradation within the gastrointestinal tract that limit their overall bioavailability. This review introduces several diverse non-oral delivery methods for the administration of statins. These alternative delivery systems and routes of administration are varied and are capable of improving the bioavailability and therapeutic efficacy of statin drugs.

KEYWORDS:

Cholesterol; Drug delivery; Parenteral; Statins

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