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Int J Environ Res Public Health. 2019 Nov 4;16(21). pii: E4273. doi: 10.3390/ijerph16214273.

Fatty Acid Profile of Postmenopausal Women Receiving, and Not Receiving, Hormone Replacement Therapy.

Author information

1
Department of Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. anna.cybulska@pum.edu.pl.
2
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland. karzyd@pum.edu.pl.
3
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland. arleta.drozd@gmail.com.
4
Student Research Association, Department of Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. k.rachubinska@gmail.com.
5
Institut für Nephrologie und Dialyse Salem-Spital, Hirslanden Bern AG, 3000 Bern, Switzerland. jola.pum@wp.pl.
6
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland. ewa.stachowska@pum.edu.pl.
7
Department of Specialized Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. anna.jurczak@pum.edu.pl.
8
Department of Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland. grochans@pum.edu.pl.

Abstract

Menopause, the permanent cessation of the menstrual cycle, marks the end of a woman's reproductive lifespan. Menopausal hormonal therapy (MHT) can potentially skew the fatty acid profile increasing the risk for developing metabolic diseases and disorders of skeletal, gastrointestinal, and nervous systems. The aim of this study was to investigate the fatty acid profile of postmenopausal women receiving, and not receiving, hormone replacement therapy. A total of 156 healthy women with a mean age of 60 participated in this cross-sectional study. Gas chromatography with an Agilent Technologies 7890A GC system was used to determine fatty acid content. Statistical analysis was conducted using R software, version 3.4.1. Women receiving MHT had significantly higher (p < 0.05) concentrations of C14:0 and C16:0. MHT was found to be associated with a tendency (p = 0.053) to diminish concentrations of C18:1n-9, C20:4, and all unsaturated fatty acids (p < 0.05). The longer MHT was used, the higher the concentration of C24:1 (p = 0.04) and the lower the concentration of C18:2n-6 (p = 0.03).

KEYWORDS:

fatty acid; menopausal hormonal therapy; menopause

PMID:
31689897
DOI:
10.3390/ijerph16214273
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