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Medicine (Baltimore). 2019 Nov;98(44):e17781. doi: 10.1097/MD.0000000000017781.

Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis.

Author information

1
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.
2
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University.
3
Biological Therapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Abstract

BACKGROUND:

Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data.

METHODS:

The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity.

RESULTS:

Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity.

CONCLUSIONS:

H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD.

PMID:
31689846
DOI:
10.1097/MD.0000000000017781
[Indexed for MEDLINE]
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