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Neurologist. 2019 Nov;24(6):180-182. doi: 10.1097/NRL.0000000000000244.

Tenecteplase Averting Mechanical Thrombectomy in Emergent Large Vessel Occlusion.

Author information

1
Stroke Unit, Metropolitan Hospital, Piraeus.
2
Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
3
Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN.
4
Department of Neurology, International Clinical Research Center, St. Anne's University Hospital in Brno, Brno, Czech Republic.

Abstract

INTRODUCTION:

Tenecteplase has recently been studied as an alternative thrombolytic agent in acute stroke, with a possible superior effect in achieving reperfusion of large intracranial vessels.

CASE REPORT:

A 90-year-old female patient was admitted to our stroke unit because of acute onset of dysarthria, left-sided neglect, and hemiparesis. Brain computed tomography (CT) coupled with CT angiography and CT perfusion (postprocessed with the use of RAPID software) demonstrated right proximal middle cerebral artery occlusion with a large penumbra/small ischemic core pattern. The patient was subsequently treated with bolus tenecteplase infusion (0.25 mg/kg). Mechanical thrombectomy was abandoned because the patient has rapidly improved. The patient was discharged to her own home 4 days later with no neurological deficit and functionally independent (modified Rankin scale of 0).

CONCLUSION:

This case exemplifies the potential of tenecteplase in achieving swift reperfusion in patients with large vessel occlusion associated with a substantial mismatch penumbral pattern.

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