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Curr Diab Rep. 2019 Nov 4;19(11):117. doi: 10.1007/s11892-019-1248-9.

The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus.

Veilleux A1,2,3, Di Marzo V1,2,3,4,5, Silvestri C6,7,8.

Author information

1
École de nutrition, Université Laval, Québec, QC, Canada.
2
Institut sur la nutrition et les aliments fonctionnels, Université Laval, Québec, QC, Canada.
3
Canadian Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Québec, Canada.
4
Institut de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, Canada.
5
Department de médecine, Université Laval, Québec, QC, Canada.
6
Canadian Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Québec, Canada. cristoforo.silvestri@criucpq.ulaval.ca.
7
Institut de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, Canada. cristoforo.silvestri@criucpq.ulaval.ca.
8
Department de médecine, Université Laval, Québec, QC, Canada. cristoforo.silvestri@criucpq.ulaval.ca.

Abstract

PURPOSE OF REVIEW:

The endocannabinoid (eCB) system, i.e. the receptors that respond to the psychoactive component of cannabis, their endogenous ligands and the ligand metabolic enzymes, is part of a larger family of lipid signals termed the endocannabinoidome (eCBome). We summarize recent discoveries of the roles that the eCBome plays within peripheral tissues in diabetes, and how it is being targeted, in an effort to develop novel therapeutics for the treatment of this increasingly prevalent disease.

RECENT FINDINGS:

As with the eCB system, many eCBome members regulate several physiological processes, including energy intake and storage, glucose and lipid metabolism and pancreatic health, which contribute to the development of type 2 diabetes (T2D). Preclinical studies increasingly support the notion that targeting the eCBome may beneficially affect T2D. The eCBome is implicated in T2D at several levels and in a variety of tissues, making this complex lipid signaling system a potential source of many potential therapeutics for the treatments for T2D.

KEYWORDS:

Bioactive lipids; Endocannabinoidome; Glucose; Insulin; Peripheral tissues

PMID:
31686231
DOI:
10.1007/s11892-019-1248-9

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