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ACS Appl Mater Interfaces. 2019 Nov 27;11(47):43976-43988. doi: 10.1021/acsami.9b17512. Epub 2019 Nov 18.

Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy.

Author information

1
Division of Biological and Environmental Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia.
2
CIC biomaGUNE , Parque Tecnológico de San Sebastián , Paseo Miramón 182 , 20014 Donostia-San Sebastián , Spain.
3
Division of Computer, Electrical, and Mathematical Sciences and Engineering , King Abdullah University of Science and Technology , Thuwal Jeddah 23955-6900 , Saudi Arabia.
4
iMdea Nanociencia, Campus Universitario de Cantoblanco , C\Faraday, 9 , 28049 Madrid , Spain.
5
Nanobiotechnology Unit (iMdea Nanociencia) associated with Centro Nacional de Biotecnología (CNB-CSIC), Campus Universitario de Cantoblanco , Madrid 28049 , Spain.
6
Ikerbasque , Basque Foundation for Science , Ma Dı́az de Haro 3 , 48013 Bilbao , Spain.

Abstract

Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core-shell nanostructure features an enhanced light-matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.

KEYWORDS:

drug delivery; iron−iron oxide core−shell; magnetic cancer therapy; nanowires; photothermal therapy

PMID:
31682404
DOI:
10.1021/acsami.9b17512

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