Format

Send to

Choose Destination
Precis Nanomed. 2019;2(1):245-248. doi: 10.33218/prnano2(1).181129.1. Epub 2019 Jan 12.

Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.

Author information

1
Department of Medicine, Washington University School of Medicine, St. Louis, MO.
2
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO.
3
Shriners Hospitals for Children - St. Louis, St. Louis.
4
Department of Cardiovascular Sciences, University of South Florida Health Heart Institute, Morsani School of Medicine, Tampa, FL.
5
Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO.
6
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
7
John Cochran VA Medical Center, Saint Louis, MO USA.

Abstract

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-κB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progression of post-traumatic osteoarthritis.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center