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Front Syst Neurosci. 2019 Oct 15;13:54. doi: 10.3389/fnsys.2019.00054. eCollection 2019.

Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections.

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Kavli Institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Laboratory of Systems Neuroscience, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka, Japan.


In the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of the lateral and medial subdivisions of the entorhinal cortex. Using elaborate quantitative retrograde tracing, complemented by anterograde tracing, we report that the layer II CB+ population comprises neurons with diverse, mainly excitatory projections. At least half of them originate local intrinsic and commissural projections which distribute mainly to layer I and II. We further show that long-range CB+ projections from the two entorhinal subdivisions differ substantially in that MEC projections mainly target field CA1 of the hippocampus, whereas LEC CB+ projections distribute much more widely to a substantial number of known forebrain targets. This connectional difference between the CB+ populations in LEC and MEC is reminiscent of the overall projection pattern of the two entorhinal subdivisions.


commissural projections; connectivity; lateral entorhinal cortex; long-range intrinsic projections; medial entorhinal cortex; parahippocampus; rodent

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